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Most gastrointestinal side effects of tirzepatide, including nausea and diarrhea, are most severe during the first few weeks of treatment or after dose increases and typically diminish within several days to weeks as the body adapts to the medication

doi: 10.1038/nature11986 66 SlaughterALDAlessandroAMooreEEBanerjeeASillimanCCHansenKCet al

Similarly, ALK inhibitors, including crizotinib, alectinib and lorlatinib, have markedly improved outcomes for patients with ALK-rearranged NSCLC, offering durable responses and enhanced quality of life (2628)