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Disclosure of interest: Nothing to disclose Poster Session II - ACUTE ISCHEMIC STROKE MANAGEMENT 01.00 - ACUTE ISCHEMIC STROKE MANAGEMENT - 01.02 - ACUTE MANAGEMENT - Thrombolysis or thrombectomy P625 - ESOC25-894 IMPACT OF PYRAMIDAL TRACTS BEYOND ASPECTS ON CLINICAL OUTCOMES IN LARGE ISCHEMIC STROKE EVALUATED BEFORE ENDOVASCULAR THERAPY Satoshi Namitome 1 , Keisuke Kawamoto 1 , Yoichiro Nagao 2 , Seigo Shindo 1 , Tadashi Terasaki 1 , Makoto Nakajima 3 1 Japanese Red Cross Kumamoto Hospital, kumamoto, Japan, 2 Saiseikai Kumamoto Hospital, kumamoto, Japan, 3 Graduate School of Medical Sciences, Kumamoto University, kumamoto, Japan Background and Aims: In endovascular therapy for stroke with a large ischemic core, the Alberta Stroke Program Early Score (ASPECTS) and core volume evaluated by preoperative imaging are recognized as predictors of good clinical outcome

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Phase 2b clinical trials were completed in Australia testing the drug in 300 obese individuals

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Important: Current published data is strictly limited to laboratory, cell culture, and preclinical animal models