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These changes are restricted to the degenerating brain regions in PD and determine regional vulnerability [103]

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Existing evidence points toward melatonins role as an antioxidant showing systemic therapeutic benefits in PD-relevant clinical trials (dyskinesia, sleep disorder) 187 , which combined with amphiphilic nature allowing for BBB diffusion further encourages therapeutic focus revisiting melatonin as a mitophagy agonist with NF-B and Nrf2 activating effect mentioned prior 187

5-year graft survival was lower in Black recipients from Black donors and White recipients from Black donors compared to White recipients from White donors

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