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Poddar K, Kolge S, Bezman L, et al

Figure 1 ALS is a fatal neurodegenerative disease characterized by progressive degeneration of both the upper and lower motor neurons, which display cytoplasmic inclusions (Rowland and Shneider, 2001

doi: 10.1016/j.taap.2021.115853 92

(2020) 36:e3213

In summary, the crosstalk between autophagy and ferroptosis is governed by a complex, context-dependent network encompassing three core modes: i) Negative regulation, primarily through mTOR signaling and mitophagy, to inhibit ferroptosis