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It demonstrates that glutathione production drives metabolic reprogramming and epigenetic modifications in monocytes, which are essential for the induction of enhanced anti-infective phenotypes characteristic of trained immunity

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PTEN loss in breast cancer is associated with resistance to chemotherapy 58 and immune checkpoint-associated immunotherapy, which may be associated with the activation of the PI3K-AKT pathway, thereby affecting T-cell infiltration in tumors 60

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