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10.1111/j.1365-2036.2011.04724.x 78 VogtN

Our study explored how cancer-related resistance could be reversed by targeting BCAA metabolism, enhancing sensitivity to radiotherapy, chemotherapy, targeted therapy, and immunotherapy

Translation to human clinical application has been narrower than the breadth of the preclinical literature would suggest

Extracellular glutamate is efficiently taken up by the sodiumdependent excitatory amino acid transporters (EAAT) 1 and 2 (Todd and Hardingham 2020), while glycine uptake is mediated by the sodiumdependent transporters GlyT1 and GlyT2 (Marques et al