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Weight loss plateaus occur in most patients due to GLP-1 receptor adaptation over time

10.1016/0092-8674(92)90163-7 Cell 132 RidleyA

These results point to a predominant role of the kidney in the hypertension that develops in mice with deficient D 2 R function

The dietary intake was assessed by obtaining a 2-day 24-h dietary recall from the participants before and after the study