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There are two alpha-2-adrenergic agonists that have some evidence as pain relievers: tizanidine (Zanaflex) and clonidine (Catapres)

Obeid et al

Autophagy and microglia: Novel partners in neurodegeneration and aging

It is not approved for human or veterinary therapeutic use, self-administration, or any clinical application

In seriously ill patients it may be advisable to administer both vitamin B12 and folic acid while awaiting the results of distinguishing laboratory studies