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Tanguy E, Wang Q, Vitale N

Concomitantly, the authors observed an increase in antioxidant enzymes, an upregulation of SIRT1 and an inhibition of NADPH oxidase 4 (NOX4)

Using BSC-40 cells, we observed that VACV significantly reduced reactive oxygen and nitrogen species levels, downregulated inducible nitric oxide synthase, and enhanced the activity of antioxidant enzymes, such as superoxide dismutase, catalase, and glutathione peroxidase

Long-term safety, repeated-dose effects, interactions with other sleep aids or hormones (such as growth hormone, cortisol, stress hormones) remain underexplored

Sandoval et al., 2019