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At the same time, To overcome the physicochemical limitations of natural compounds and their undesirable pharmacokinetic properties such as poor absorption, distribution, metabolism, and excretion in vivo, the design and application of nanocarriers has attracted extensive attention leading to nanocarrier-based drug delivery systems

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After the experiment, the cell number was determined by CyQUANT (Invitrogen, #C35011) for normalization