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Moreover, potential therapeutic approaches that prevent eNOS uncoupling by improving cofactor availability, restoration of L-Arg/ADMA ratio, or modulation of eNOS S-glutathionylation are briefly outlined

Research on patient preferences consistently shows overwhelming preference for nasal formulations, with feedback describing them as fastest and simplest. The elimination of needle-related anxiety, pain, and the need for sterile technique significantly reduces barriers to consistent therapy adherence

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