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doi: 10.1021/pr8004925 23 FutatsuyaT.UshigamiT.NomuraF.AnzawaK.MochizukiT.ChoO.et al

demonstrated that oxidative stress and H 2 O 2 treatment led to a marked increase in senescence-associated -galactosidase activity but only to minimal apoptotic cell death in CSCs, suggesting that ROS triggered the induction of senescence and exhibited therapeutic potential in the eradication of drug-resistant CSCs [8]