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Dieni S, Matsumoto T, Dekkers M, Rauskolb S, Ionescu MS, Deogracias R, Gundelfinger ED, Kojima M et al (2012) BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons

Elevated levels of ROS increase the incidence of mtDNA mutations [41], and the accumulation of induced mtDNA mutations as well as restricted DNA repair capacity, together with errors during replication, lead to increased DNA damage and chromosome damage [42, 43]