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J Bacteriol 192(5):12311237 Shaffer CL, Good JA, Kumar S, Krishnan KS, Gaddy JA, Loh JT, Chappell J, Almqvist F, Cover TL, Hadjifrangiskou M (2016) Peptidomimetic small molecules disrupt type IV secretion system activity in diverse bacterial pathogens

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The key distinction is not stability, but contamination control

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These results and a few pieces of previous evidence indicate that melittin, compared with other bee venom ingredients, possesses broader therapeutic effects on CIPN (Choi et al., Our electrophysiological data revealed a marked reinforcement of spontaneous activity within spinal WDR neurons under paclitaxel-induced neuropathic states (Figure 4A)

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[ 12 , 16 ] Researchers hypothesize that this mechanism could contribute to some of the sleep-related effects reported in early studies

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