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3.1.1 The role of Se in GD A large number of studies have now confirmed Se deficiency as a risk factor for GD in areas with adequate soil Se levels ( Based on the damage to thyroid cells caused by low Se level, researchers have raised the possibility that Se supplementation may be beneficial in GD and have conducted a series of clinical studies ( Although the current findings are ambiguous and evidence from clinical trials does not favor the use of Se as a routine treatment option in GD, nor does the use of Se supplementation affect the remission and recurrence rates of GD ( 3.1.2 The role of Se in GO Current studies suggest that fibroblasts are distributed in the posterior globular connective tissue and ocular myofilament

Evidence: A small uncontrolled study (n=12) by Sinha et al

Hydrogen-Rich Saline Ameliorates Allergic Rhinitis by Reversing the Imbalance of Th1/Th2 and Up-Regulation of CD4+CD25+Foxp3+Regulatory T Cells, Interleukin-10, and Membrane-Bound Transforming Growth Factor- in Guinea Pigs

J Clin Biochem Nutr 65:52

Peptides 109:2332