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However, the fact that AOXs are largely available over-the-counter with a reasonable price increases the risk that some patients can overmedicate with AOXs leading to detrimental effects

471 Moreover, disruptions in desmin filaments or costamere components can weaken the structural integrity of the muscle fiber, diminishing the muscles ability to transfer force and withstand mechanical stress

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The livers contribution to blood acylcarnitine levels is also closely related to the risk of cardiovascular events

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