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The enzyme glutathione reductase (GR) recycles GSSG to GSH while simultaneously oxidizing ?-nicotinamide adenine dinucleotide phosphate (?-NADPH2)

The mechanisms of natural products in regulating Nrf2-associated cellular processes were summarized and tabulated in Table 2

283,284,285 PEG modification can inhibit the binding of apolipoprotein E to LNPs, a key mechanism for LNP uptake by the liver, thereby affecting liver uptake of LNPs

Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity