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Upon coupling of the two intermediates amine 3 and CPO-PFP, linker CCA was obtained in high yield

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A randomized double-blind placebo-controlled phase IIB trial treated patients with oral leukoplakia using curcumin (3.6 g daily for 6 months) and noted a significant and durable clinical response, including reduction in lesion size and histopathological improvement in terms of reduced dysplasia in some cases (Kuriakose et al., 2016)

Clinical Chemistry, 34 (3), 497500