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Brain 145 , 4563 (2022)

Silibinin is a flavonolignans component extracted from silymarin, which has anti-inflammatory, anti-infective, and anti-tumor effects

The combination of three biomarkers (higher GGT, C-reactive protein and fasting glucose) identified a group of patients (n=45) with a 3-year risk of cardiac mortality of 26.6% (40)

In rats, dogs, and swinethe three species where both compound classes have been extensively characterizedcombined administration produces peak GH levels 2- to 5-fold higher than predicted from additive effects

The choice of a 10 L intratesticular volume was based on previously published work in rat testicular ischemiareperfusion models that used the same order of magnitude for local injections and reported both technical feasibility and biological efficacy without mechanical damage to the testis