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Mittal et al., 2014)

doi: 10.1016/j.mib.2017.07.003

Drug-induced or chemical-induced toxicity Some clinical drugs of abuse have been demonstrated to induce organ-specific toxicity, a phenomenon that may involve the involvement of ROS

Another challenge to overcome for the next-generation nanomedicines resides in the regulatory classification, because the lack of knowledge regarding biosafety and long-term effects of nanomaterials leads to a regulatory uncertainty and deficient standards and protocols for scale-up manufacturing and safe clinical uses [678,679]