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We found that PPARA was one of the most interacting genes of this interactome (Supplementary Fig

Alon L, Nir S, Justin C Y W, Uri K, Adi L, Ofir H-N et al

GLP-1 receptor agoniststhe class of drugs that includes semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), and tirzepatide (Mounjaro, Zepbound)are synthetic molecules engineered to mimic and amplify this exact hormonal signal

Massive smooth muscle cell apoptosis occurs and is replaced by collagen fibers, whereas myofibroblast activation and proliferation enter an exhausted phase, leading to a significant decline in -SMA synthesis capacity