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These landmark studies showed that mice with adipose-tissue-specific NNMT knockout remained lean when fed high-fat diets that caused wild-type mice to become obese, and that these protected mice had increased energy expenditure, enhanced fatty acid oxidation, improved glucose tolerance, and elevated NAD+ levels in adipose tissue

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Proc Natl Acad Sci U S A (2008) 105:618590.10.1073/pnas.0801447105 21 NencioniLIuvaraAAquilanoKCirioloMRCozzolinoFRotilioGet alInfluenza A virus replication is dependent on an antioxidant pathway that involves GSH and Bcl-2

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Chronic treatment with N-acetylcysteine decreases extinction responding and reduces cue-induced nicotine-seeking