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The enzymatic pathways involved in H 2 S metabolism are per se sources of low molecular weight per-sulphides and poly-sulphides

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Sublingual administration achieves 55% penetration after 10 minutes and approximately 70% after 30 minutes through oral epithelium

These new findings encourage a novel working hypothesis for further research, that a chemical-modification mechanism enables transformation of HGF through interaction or reaction with LASSS under physiological conditions, resulting in the retention of HGFs biological activity after exposure to peroxynitrite, at least until an enhanced form of HGF undergoes metabolic turnover in vivo