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IGF-I and -II had actions through the type 1 IGF receptor (IGF1R) demonstrated by Igf1r ko animals with 45% of wild type birth weight and no further effect when crossed with Igf1 ko animals

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This occurs through the direct impact of the peptide on body fat tissue, whereby it activates the beta-3 adrenergic receptor(s) involved in the fat-burning process within the body

Therefore, 23 clinical studies published from 2020 to 2025 are presented from various countries that examined oral collagen supplementation in women who were aged 30 to over 65 years (Table 1)