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Silva AC, dos Santos AGR, Pieretti JC, Rolim WR, Seabra AB, vila DS

Both BPC-157 and TB-500 exert anti-inflammatory effects relevant to tissue repair biology , with BPC-157 characterised as suppressing pro-inflammatory cytokine production, reducing neutrophil and macrophage infiltration at injury sites, and modulating the balance between inflammatory and resolving phases of tissue repair

We treated TC1-6 cells with serum collected from WT or GCGR-KO mice for 72 h and found that VGF and proglucagon protein levels were significantly increased in GCGR-KO serum-treated cells (Fig

however, many questions remain unanswered

Given that there is no placebo-controlled human data, no established dose, and a mechanism whose foundational papers were retracted, an absence of noticeable effect is fully consistent with the current evidence it does not necessarily indicate a defective product, the wrong route, or an insufficient duration