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At the cellular level, these insults trigger distinct pathogenic pathways

GaoGXieZLiEYuanYFuYWangPet alDehydroabietic acid improves nonalcoholic fatty liver disease through activating the Keap1/Nrf2-ARE signaling pathway to reduce ferroptosis

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however, MLKL knockout mice remained susceptible to APAP-induced liver injury, indicating that necroptosis is not the primary mode of cell death in APAP-induced toxicity