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Another option for direct targeting could occur via NPC1L1

Toxicological & Environmental Chemistry

(B) Regulation of LRRC8/VRACs current by oxidizing and reducing agents depending on the subunit's composition of VRAC

In vitro studies demonstrate that BPC-157 promotes survival of cells exposed to various stressors including oxidative damage, toxic substances, and serum deprivation

In past, several studies suggested involvement of plant GST gene family in As response due to the requirement of sulfur and GSH in the detoxification of this toxic metalloid