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KEY FINDINGS To start, we analysed publically available sequencing data of cancer patient samples and found that the expression of serine and glycine synthesis enzymes was significantly increased in T-cell leukaemia patient samples that present NKX2-1 overexpression (Figure 2)

Abbreviations NMN: (nicotinamide mononucleotide) ALD: (Alcoholic liver disease) NAD + : (Nicotinamide adenine dinucleotide) SIRT1: (Sirtuin 1) NMNAT: (Nicotinamide mononucleotide adenylyl transferase) NAMPT: (Nicotinamide Phosphoribosyltransferase) CYP2E1: (Cytochrome P-450 2E1) ALT: (Alanine aminotransferase) AST: (Aspartate aminotransferase) TC: (Cholesterol) TG: (Triglyceride) MDA: (Malondialdehyde) SOD: (Superoxide dismutase) GSH: (Glutathione) PCR: (Polymerase Chain Reaction) WB: (Western Blotting ) ELISA: (Enzyme-Linked Immunosorbent Assay) HE: (Hematoxylin-eosin) TNF-: (Tumor necrosis factor-) IL-6: (Interleukin-6) IL-1: (Interleukin-1) ROS: (Reactive oxygen species) GAPDH: (Glyceraldehyde-3-phosphate dehydrogenase) ATP: (Adenosine Triphosphate) ADP: (Adenosine Diphosphate) ZO-1: (Zonula Occludens-1 Protein) PMSF: (Phenylmethylsulfonyl fluoride) RIPA: (Radio immunoprecipitation assay) SDS: (Sodium dodecyl sulfate) TEMED: (Tetramethylethylenediamine) TBST: (Tris-Buffered Saline with Tween-20) PVDF: (Polyvinylidene fluoride) TBS: (Tris Buffered Saline) SDS-PAGE: (Sodium dodecyl sulfate - polyacrylamide gelelectrophoresis) References Lim SS, Vos T, Flaxman AD et al