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Description

Geranylgeranyl diphosphate synthase: an emerging therapeutic target

Reduction in Cellular Glutathione A lack of magnesium lowers glutathione levels in cells, making them more prone to damage

Under normal circumstances, hepcidin is mainly synthesized in the liver and binds to ferroportin on the cell membrane, promoting its internalization and degradation, thereby reducing the release of intracellular iron[52]

ACLY is regulated by the Akt-mTORC1 axis, and IL-4 activates the Akt-mTORC1 signaling pathways, increasing histone acetylation and inducting M2 gene expression, resulting in M2 macrophage activation (130)