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Brault, C

Isolated reports suggest creatine may be associated with various side effects affecting several organ systems including skeletal muscle, the kidney and the gastrointestinal tract, stated a review in Sub-Cellular Biochemistry

315 This interaction significantly reduces the availability of essential costimulatory signals for effector T cells, leading to diminished activation, proliferation, and antitumor function of these cells (Fig

Given the pathogenic significance of ABCs and DNs in systemic autoimmune diseases, numerous research groups have directed their efforts toward developing therapeutic strategies that specifically target these B cell populations