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Unnatural amino acids: Promising implications for the development of new antimicrobial peptides

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The central activation on the hypothalamus contributes to robust regulation of appetite and satiety, while peripheral effects on the gastrointestinal system lead to improved glycemic outcomes

Here we present the cryo-electron microscopy structure of Cdiff RNA polymerase in complex with fidaxomicin and identify a crucial fidaxomicin-binding determinant of Cdiff RNA polymerase that is absent in most gut microbiota such as Proteobacteria and Bacteroidetes

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