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It is unclear whether study was performed

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Optimising thiopurines, including with the use of concomitant allopurinol, therefore remains an important option for IBD clinicians, and potentially those managing other immune-mediated inflammatory diseases

doi: 10.1016/j.pharmr.2025.100051 55

454 In glaucoma mice, mitophagy may also be downregulated, and the mitophagy marker Rheb was observed to be weakened in the retina, 455 so the damaged mitochondria are difficult to be cleared by mitophagy