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In particular, TFEB family members are orphan of a TOS motif and are instead recruited to mTORC1 through a direct interaction with the RagC GTPase ( ON , TFEB is sensitive to any perturbation that would result in a change in the nucleotide to which RagC is bound, such as nutrient withdrawal/replenishment, but would be less affected by the inhibition and activation of the growth factor signaling cascade

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10.1371/journal.pone.0203350 78 SummermatterS.SantosG.Prez-SchindlerJ.HandschinC

A third question is related to the pleiotropic effects of SLC39A8 mutations