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Severe AMS, however, is associated with the development of other high-altitude illnesses, such as high-altitude cerebral edema (HACE) and/or high-altitude pulmonary edema (HAPE), both potentially life-threatening and characterized by vasogenic edema, altered vascular permeability, and neurological or respiratory dysfunction (Moraga et al., 2007

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The peptide works through multiple mechanisms including enhanced angiogenesis (blood vessel formation), increased collagen synthesis, and activation of growth hormone receptors on fibroblasts

doi: 10.1371/journal.pone.0116775 267 HeCLarson-CaseyJLGuLRyanAJMurthySCarterAB

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