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Analysis of existing feline and canine clinical studies reveals that IV injection remains overwhelmingly dominantwhether in early exploratory studies or recent randomized controlled trials, the vast majority have employed the IV route (2830, 53, 123131)

These are usually transient and dose-dependent

Furthermore, mRNA levels of NAD(P)H quinone oxidoreductase 1 (Nqo1) and haem oxygenase 1 (Hmox1), which are known targets of Nrf2 (Nfe2 like bZIP transcription factor 2), were downregulated in the liver of aspartame-exposed mice compared with the control group (Finamor et al., 2021)