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Thus, therapeutic enhancement of the functions of MerTK + CD206 + STM clusters by activation of MerTK with agonists, could facilitate restoration of synovial homeostasis ( + lining macrophages limiting the inflammatory response by providing tight junction-mediated shielding for intra-articular structures (Kurowska-Stolarska and Alivernini, 2022

The kidney tissues were homogenized with PBS and then centrifuged at 4 C for 15 min at 3000 rpm

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It's also studied for bone density and connective tissue health through the GH and IGF-1 signalling cascade

Evidence comparison: TB-500 has a more extensive preclinical evidence base for systemic tissue repair, including corneal wound healing, cardiac repair, and neurological recovery