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Zec I, Goldtajn M, Kuna K, et al

The delicate periorbital skin responds well to copper peptides for dark circles and fine lines, but requires careful formulation to avoid irritation

GHK-Cu is a copper peptide found in human plasma and saliva

For instance, female mice administered BSO exhibited much higher susceptibility to acetaminophen-induced hepatotoxicity than male mice [43], while male mice treated with BSO were much more susceptible to thiabendazole nephrotoxicity than females [44]