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Furthermore, excessive activation of the AGE/RAGE signaling pathway exacerbates oxidative stress and mitochondrial dysfunction in sepsis (Xie et al., 2024

Moreover, two main types of receptor-mediated mitophagy pathway have been classified as follows in brief: ubiquitin-independent mitophagy receptors, including BCL2-interacting protein 3 (BNIP3) (Quinsay et al., 2010), BCL2-interacting protein 3 like (NIX/BNIP3L) (Sandoval et al., 2008), FUN14 domain-containing 1 (FUNDC1) (Liu et al., 2012), BCL2-like 13 (BCL2L13) (Otsu et al., 2015), autophagy and beclin 1 regulator 1 (AMBRA1) (Strappazzon et al., 2015), FKBP prolyl isomerase 8 (FKBP8) (Wei et al., 2017), and NLR family member X1 (NLRX1) (Zhang et al., 2019)

9, e15613

doi: 10.1080/21655979.2021.1951070 94 YeSXuMZhuTChenJShiSJiangHet al

Gamma-glutamylisoleucine was identified as a key metabolite candidate