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When tumors reached approximately 100 mm 3 , mice were randomized into four groups (sh-NC + vehicle, sh-GPX3 + vehicle, sh-NC + PX-478, sh-GPX3 + PX-478) and treated orally with the HIF-1 inhibitor PX-478 (20 mg/kg) or vehicle for five consecutive days (Fig

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Transmission electron micrographs revealed that combination induces significative internal damage TEM analysis was employed to investigate and compare ultrastructural damages induced by AS, RESV alone or in combination (AS + RESV) (Fig

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