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Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model

Loss of PRX1 in mouse embryonic fibroblasts led to the accumulation of ROS, increased p16 expression and senescence-associated -galactosidase activity, classical markers of senescence (Park et al., 2017)

doi: 10.1515/bmc-2020-0021 176 VigM.KinetJ.-P

As collagen strengthens, skin can look plumper and feel firmer, and as elastin improves, skin can rebound more easily instead of looking slack or creased