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For instance, Pdp1 binds to H4K20me1 to facilitate chromatin maturation, whereas 53BP1 in mammals and Crb2 in fission yeast selectively bind the H4K20me2, required for DNA damage checkpoint activation [54]

Interestingly, these seemingly dichotomous effects of E2 on intracellular bioenergetics could be a result of differential receptor activation, as E2 was found to inhibit F0F1-ATP synthase activity via non-genomic mechanisms in a human osteoclastic cell line (FLG 29.1 cells) (200)

Lower estrogen, reduced activity over time, and menopause-related sleep disruption often work together to drive steady weight gainabout 1.5 pounds per year on average after menopause