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2016;1:e0163716

It also increases aquaporin-4 (AQP-4) involved in glial edema (47), and poli ADP-ribose polymerase-1 (PARP-1) that favors necrosis through glial activation (48)

NADPH depletion and accumulation of disulfides causes disulfide stress, and then this stress activates some signaling pathways, leading to aberrant disulphide bonds and disulfidptosis in actin cytoskeleton [6]

Additionally, Zhang et al

[13] Ascorbic acid and sulfites are reducing agents that reduce quinones back to the original colorless phenols, or that react irreversibly with quinones to form stable colorless products