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Only then can the cobalt atom be reduced from an oxidative state of +3 to the biologically active +1, forming methyl B12 in the cytosol, and adenosyl B12 in the mitochondria

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minor injection site reactions usually resolve within days Sharps containers must be used for needle disposal and returned via GP practices, pharmacies, or local authority collection schemes Patients with neurological symptoms may require alternate-day injections initially before transitioning to maintenance dosing schedules Table of Contents What Are B12 Injections and Who Needs Them