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Advances in diagnostic strategies, including quantitative imaging modalities and circulating biomarkers, alongside ongoing progress toward laboratory determinants and assay standardization, have begun to refine disease characterization and translational potential, though consensus remains limited

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Among the systems of retinal cells to mitigate ROS and manage oxidative stress, a principal one is glutathione (GSH), and it relies on nicotinamide adenine dinucleotide phosphate (NADPH) 1

Reactive oxygen species are also formed as necessary intermediates in a variety of enzyme reactions

Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of leukemia cell lines and patient samples