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Transcranial direct current stimulation based metaplasticity protocols in working memory

Wu X, Zhang F, Mao X, Xu F, Ding X, Sun X, et al

GCL, heterodimer made up of the heavy sub unit (73 kDa) has the catalytic activity (GCLC), and is the site of GSH feed back inhibition The light (30 kDa) or modifier (GCLM) sub unit, alter, or regulate the activity of the holoenzyme Glutamate cysteine ligase (GCL) L-glutamate + L-cysteine + ATP -L-glutamyl-L-cysteine + ADP + Pi GCL is regultate physiologically by : Feed back competitive inhibition by GSH The availability of its precurser, L-cysteine

These findings highlight the importance of personalised treatment approaches that balance efficacy with the risk of toxicity, along with careful monitoring and supportive care to mitigate adverse effects