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Description

Obesity, expression of adipocytokines, and macrophage infiltration in canine mammary tumors

doi:10.1152/ajprenal.00551.2017 Le Vaillant J, Pellerin L, Brouard J, Eckart P

944 The acidic conditions present at tumor sites stimulates the release of oleanolic acid and LOX, with oleanolic acid upregulating the expression of ACSL4 and collaborating with LOX to promote enzyme-mediated lipid peroxidation

In addition, microglial exosomes can function as independent metabolic units and have the potential to increase glucose-based energy outside of mitochondria in recipient cells (Iraci et al., 2017)

Thus, the RAS/MAPK pathway can induce ferroptosis by enhancing the expression of ACSL4, which in turn affects the PUFA oxidation process and ultimately leads to the accumulation of lipid peroxides