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Changes to the unfolded protein response (UPR) and autophagy pathways reduce clearance of misfolded proteins [211]

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Attentional set-shifting : cognitive flexibility, rodent equivalent of Wisconsin Card Sorting

Tea polyphenols counteract this by enhancing cellular antioxidant defenses, stimulating the Nrf2-Keap1-ARE signaling pathway, while suppressing the NF-B signaling pathway ( 5.4 The role of sulforaphane in the treatment of kidney stones SFN (sulforaphane), is an isothiocyanate produced through glucosidase hydrolysis in cruciferous plants, known for its antioxidant properties ( Figure 3 )