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2 In this review, we discuss evidence suggesting that some effects of oxidative stress in tumors may be mediated by a family of lipid peroxidation products called oxidized phospholipids (OxPLs, Figure 1 )

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Mitochondria, which retain ancestral bacterial motifs, are released into the cytosol or extracellular space as DAMPs upon cellular damage and are sensed by innate immune receptors to initiate inflammatory and antimicrobial defense responses