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Most critically, there remains no universally agreed-upon cutoff value for defining hormone sensitivity or high OS status, further hindering its standardized application

According to a 2024 review, There were no serious adverse events attributed directly to [urolithin A] reported in any of the studies

Determining if the EHBDs are involved is important as currently most research focuses on the liver parenchyma and the intrahepatic biliary tree without looking at the EHBD, which are known to be affected in the majority of PSC patients 6

These findings support the classification of AA as a systemic disease

Goriely S, Goldman M