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Contact your GP if you experience: No improvement after 46 weeks of treatment : Whilst neurological symptoms may take longer to resolve, you should notice some improvement in energy levels or general wellbeing within this timeframe

Chronic joint pain Persistent joint issues that haven't fully resolved with physical therapy, rest, or standard anti-inflammatory treatment

Well-structured treatments lasting 6-12 months with appropriate concentrations typically maintain noticeable improvements over pre-treatment baseline including reduced fine lines (though not eliminated as during peak treatment), improved skin texture and firmness (though less dramatic than treatment peak), better overall skin quality and appearance (though aging continues at normal rates), and resolved specific issues like scarring or hyperpigmentation (which typically remain improved permanently if successfully treated)

10.1016/j.jalz.2019.07.002 Alzheimers Dement

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